PXD006828-1

PXD006828 is an original dataset announced via ProteomeXchange.

Title	PRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core
Description	In the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translational modifications: arginine methylation and ubiquitination. While monomethylated HBc retains cytoplasmic localization, symmetric dimethylation is linked to serine phosphorylation and nuclear transport. Thus arginine methylation and ubiquitination are novel types of HBc post-translational modifications which add another level of complexity to the understanding of HBc function and regulation of HBV replication
HostingRepository	PRIDE
AnnounceDate	2017-11-01
AnnouncementXML	Submission_2017-11-01_03:46:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Hubalek
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitinylated lysine; dimethylated L-arginine; phosphorylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-29 01:56:50	ID requested
⏵ 1	2017-11-01 03:46:39	announced
2	2024-10-22 04:39:51	announced	2024-10-22: Updated project metadata.

Lubyova B, Hodek J, Zabransky A, Prouzova H, Hubalek M, Hirsch I, Weber J, PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core. PLoS One, 12(10):e0186982(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Hepatitis B Virus, HBV Core protein, Arginine methylation, Ubiquitination, phosphorylation

Martin Hubalek
contact affiliation	Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences
contact email	hubalek@uochb.cas.cz
lab head
Martin Hubalek
contact affiliation	Institute of Organic Chemistry and Biochemistry, Czech Academy of Science
contact email	hubalek@uochb.cas.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD006828

PRIDE project URI

• PRIDE
  1. PXD006828
     1. Label: PRIDE project
     2. Name: PRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core