PXD006812-2

PXD006812 is an original dataset announced via ProteomeXchange.

Title	PDGF-hSyn Synaptosomes (vGlut FASS) nanoLC-MS/MS
Description	This project studies the differential abundance of proteins at excitatory synapses of PDGF-hSyn mice (Masliah et al., 2000, Science), which are a model for Parkinson’s disease/dementia with Lewy bodies. The mice overexpress human alpha synuclein under the human PDGF promoter. Synapses were purified from animals expressing fluorescently tagged vGlut1 (vGlut1-Venus) using fluorescence activated synapse sorting (FASS; cf. Biesemann et al., 2014, EMBO J).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:57:56.983.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Dorostkar
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-27 07:12:12	ID requested
1	2019-09-02 11:40:01	announced
⏵ 2	2024-10-22 04:58:02	announced	2024-10-22: Updated project metadata.

10.1007/s00401-019-02063-3;

Blumenstock S, Angelo MF, Peters F, Dorostkar MM, Ruf VC, Luckner M, Crux S, Slapakova L, Arzberger T, Claverol S, Herzog E, Herms J, -synucleinopathy. Acta Neuropathol, 138(6):971-986(2019) [pubmed]

curator keyword: Biological

submitter keyword: vGlut, Lewy body,Synaptosome, Excitatory synapse, Parkinson’s diseas

Mario Dorostkar
contact affiliation	Ludwig-Maximilians; University Munich; Germany
contact email	mario.dorostkar@med.uni-muenchen.de
lab head
Mario Dorostkar
contact affiliation	LMU Munich
contact email	mario.dorostkar@med.uni-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD006812

PRIDE project URI

• PRIDE
  1. PXD006812
     1. Label: PRIDE project
     2. Name: PDGF-hSyn Synaptosomes (vGlut FASS) nanoLC-MS/MS