PXD006769-3

PXD006769 is an original dataset announced via ProteomeXchange.

Title	Phosphotyrosine profiling of in vivo signaling changes in erlotinib-treated glioblastoma flank xenografts
Description	Mass spectrometry-based quantitative proteomics profiling of in vivo signaling changes in 16 GMB xenograft tumors treated with vehicle and erlotinib (5 mg/kg, 33 mg/kg, 100 mg/kg).
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:38:35.916.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD006769
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Kristina Bennet Emdal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-06-21 03:26:40	ID requested
1	2018-11-06 07:42:04	announced
2	2019-04-03 04:30:03	announced	Updated publication reference for PubMed record(s): 30464169.
⏵ 3	2024-10-22 04:38:44	announced	2024-10-22: Updated project metadata.

10.1038/s41467-018-07334-3;

Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL, Johnson AJ, Lu FK, Xie XS, Joughin BA, Reddy RJ, Peng S, Abdelmoula WM, Jackson PR, Kolluri A, Kellersberger KA, Agar JN, Lauffenburger DA, Swanson KR, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR, Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma. Nat Commun, 9(1):4904(2018) [pubmed]

10.6019/PXD006769;

curator keyword: Biomedical

submitter keyword: erlotinib, tyrosine phosphorylation, xenografts, mass spectrometry,Glioblastoma, EGFR

Forest White
contact affiliation	Massachusetts Institute of Technology
contact email	fwhite@mit.edu
lab head
Kristina Bennet Emdal
contact affiliation	Massachusetts Institute of Technology
contact email	kbemdal@mit.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/11/PXD006769

PRIDE project URI

• PRIDE
  1. PXD006769
     1. Label: PRIDE project
     2. Name: Phosphotyrosine profiling of in vivo signaling changes in erlotinib-treated glioblastoma flank xenografts