PXD006460-1

PXD006460 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics study of Mecp2 KO versus wild type mice
Description	Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. RTT is characterized by having apparently normal development until 6-18 months, when a progressive decline in motor and language functions begins and breathing abnormalities and seizures present. Here we present the first proteomic analysis in a RTT mouse model. Examining whole cortex tissue in symptomatic males (Mecp2Jae/y) and wild-type littermates, we have identified 465 proteins significantly altered. Pathway analysis identified biological pathways ubiquitous to multiple cell types as well as cell type specific pathways, underscoring the contributions of multiple central nervous system (CNS) cell populations to the disease pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2017-11-02
AnnouncementXML	Submission_2017-11-02_05:05:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Heaven
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-05-08 01:26:13	ID requested
⏵ 1	2017-11-02 05:05:09	announced

Pacheco NL, Heaven MR, Holt LM, Crossman DK, Boggio KJ, Shaffer SA, Flint DL, Olsen ML, -deficient mice, a model for Rett syndrome. Mol Autism, 8():56(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Rett syndrome, DIA, mouse brain cortex

Michelle Olsen
contact affiliation	Associate Professor Virginia Tech
contact email	molsen1@vt.edu
lab head
Michael Heaven
contact affiliation	Vulcan Analytical
contact email	mike@vulcan.ms
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD006460

PRIDE project URI

• PRIDE
  1. PXD006460
     1. Label: PRIDE project
     2. Name: Quantitative proteomics study of Mecp2 KO versus wild type mice