PXD006357-1

PXD006357 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
Description	Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic capacity for distinguishing the two syndromes resulting in broader antibiotic cover than necessary. A biochemical marker of ABM would facilitate precise clinical diagnosis and management of these infections. In this study, we used Label-free protein quantification by mass spectrometry to identify components of the CSF protein expression profiles of children with ABM that distinguish from those with CM with a high degree of specificity and sensitivity and that could be developed into point-of-care tests. James M. Njunge, Ian N. Oyaro, Nelson K. Kibinge, Martin K. Rono, Symon Kariuki, Charles R. Newton, James A. Berkley, Evelyn Gitau
HostingRepository	MassIVE
AnnounceDate	2017-04-24
AnnouncementXML	Submission_2017-04-24_03:02:50.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	James Njunge
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	N-acetylated residue; Carbamidomethyl
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-04-24 01:23:25	ID requested
⏵ 1	2017-04-24 03:02:51	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Biomarkers, Acute Bacterial Meningitis, Cerebral Malaria, Cerebrospinal Fluid, proteomics, Q Exactive, Label Free Quantification

submitter keyword: Biomarkers, Acute Bacterial Meningitis, Cerebral Malaria, Cerebrospinal Fluid, proteomics, Q Exactive, Label Free Quantification

Contact List

James M. Njunge
contact affiliation	KEMRI-Wellcome.org
contact email	jnjunge@kemri-wellcome.org
lab head
James Njunge
contact affiliation	KEMRI Wellcome Trust Programme
contact email	jnjunge@kemri-wellcome.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080979