PXD006214-1

PXD006214 is an original dataset announced via ProteomeXchange.

Title	Mouse hippocampus LC/MS with TMT labeling
Description	Transgenic mouse models have been widely used to investigate the pathology of Alzheimer’s disease (AD). To elucidate underlying mechanisms of AD pathogenesis by amyloid beta (Aβ) and tau, we have generated a novel animal model of AD; ADLP - APT mice (Alzheimer’s Disease-Like Pathology) – carrying mutations of human amyloid precursor protein (APP), human presenilin-1 (PS1) and human tau. We profiled 9,824 proteins in the hippocampus of ADLP model mice using quantitative proteomics. To identify functional signatures in pathology of ADLP - APT mice, in-depth bioinformatics analysis was performed. For a longitudinal change of differentially expressed proteins (DEPs), we identified ADLP - APT mice hippocampal proteome in an age-dependent manner. Network maps of interactome between Aβ and tau in newly generated ADLP - APT mice reveal relationship between accelerated NFT pathology of AD and proteomic changes.
HostingRepository	PRIDE
AnnounceDate	2018-01-25
AnnouncementXML	Submission_2018-01-25_02:25:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dohyun Han
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-30 01:57:49	ID requested
⏵ 1	2018-01-25 02:25:55	announced

Kim DK, Park J, Han D, Yang J, Kim A, Woo J, Kim Y, Mook-Jung I, Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics. Mol Neurodegener, 13(1):2(2018) [pubmed]

curator keyword: Biological

submitter keyword: Mouse, Hippocampus, LC/MS, TMT

Dohyun Han
contact affiliation	Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Seoul, Korea
contact email	hdh03@snu.ac.kr
lab head
Dohyun Han
contact affiliation	Biomedical Research Institute, Seoul National University Hospital
contact email	hdh03@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD006214

PRIDE project URI

• PRIDE
  1. PXD006214
     1. Label: PRIDE project
     2. Name: Mouse hippocampus LC/MS with TMT labeling