PXD005997-1

PXD005997 is an original dataset announced via ProteomeXchange.

Title	Analysis of phosphorylation sites in CLL samples
Description	The profiling of B-cell chronic lymphocytic leukemia (B-CLL) cells at the protein level is still a major goal for advancing targeted personalized therapies. Understanding how B cells become malignant would be supported by the description of predicted responses to kinase inhibitors as nearly all cancers are guided by deregulation of protein kinase networks. In this sense, the present project looks for the profiling of the phosphopetides present in the B-CLL proteins together with the full characterization of their proteome.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_06:05:59.845.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paula Díez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-03-01 08:57:15	ID requested
⏵ 1	2025-05-13 06:06:00	announced

D, í, ez P, Juanes-Velasco P, Garc, í, a-Vaquero ML, Droste C, Landeira-Vi, ñ, uela A, Alcoceba M, Fidalgo-G, ó, mez H, Misiego-Herrero S, Navarro-Bail, ó, n A, Baile M, Bastida JM, Sanchez-Santos JM, G, ó, ngora R, Almeida J, Gonzalez-Diaz M, Orfao A, De Las Rivas J, Fuentes M, Tonic signaling of the B-cell antigen-specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages. Mol Oncol, ():(2025) [pubmed]

10.1002/1878-0261.70032;

submitter keyword: PTM, CLL, B cells

Manuel Fuentes
contact affiliation	Laboratory 11 and Proteomics Unit. Cancer Research Center. Salamanca. Spain
contact email	mfuentes@usal.es
lab head
Paula Díez
contact affiliation	Cancer Research Institute-USAL
contact email	pauladg@usal.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD005997

PRIDE project URI

• PRIDE
  1. PXD005997
     1. Label: PRIDE project
     2. Name: Analysis of phosphorylation sites in CLL samples