PXD005935-1

PXD005935 is an original dataset announced via ProteomeXchange.

Title	HLA DR1 and DR15 ligands isolated from transgenic mice
Description	Dominant protection from HLA-associated autoimmune disease is conferred by antigen specific regulatory T cells. Susceptibility and protection against human T cell mediated autoimmune diseases, including type I diabetes, multiple sclerosis and Goodpasture’s disease, is associated with particular Human Leukocyte Antigen (HLA) alleles. However, the mechanisms underpinning such HLA-mediated effects on self-tolerance, and the interplay with the responding autoreactive T cell repertoires, remain unclear. To address this central question, we investigated the molecular mechanism of Goodpasture’s disease, an HLA-linked autoimmune renal disorder characterized by an immunodominant CD4+ T cell self-epitope derived from the alpha3 chain of Type IV collagen (alpha3135-145). While HLA-DR15 confers a markedly increased disease risk (odds ratio 8.5), the protective HLA-DR1 allele (odds ratio 0.3) is dominantly protective in trans with HLA-DR15 (odds ratio 1.4). This dataset contains RAW data and database search results identifying the HLA-bound peptides from transgenic mice expressing either human HLA-DR1 or -DR15.
HostingRepository	PRIDE
AnnounceDate	2017-05-04
AnnouncementXML	Submission_2017-05-04_04:11:27.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sri Ramarathinam
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-02-20 01:37:48	ID requested
⏵ 1	2017-05-04 04:11:29	announced
2	2024-10-22 04:36:20	announced	2024-10-22: Updated project metadata.

Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR, Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature, 545(7653):243-247(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: mouse, HLA class II, DR1, DR15, Goodpasture’s disease

Anthony W Purcell
contact affiliation	Professor Anthony W Purcell Deputy Head (Research), Department of Biochemistry and Molecular Biology Head Immunoproteomics Laboratory Monash University, Clayton Campus Clayton 3800 Victoria Australia
contact email	anthony.purcell@monash.edu
lab head
Sri Ramarathinam
contact affiliation	Monash University
contact email	sri.ramarathinam@monash.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005935
     1. Label: PRIDE project
     2. Name: HLA DR1 and DR15 ligands isolated from transgenic mice