PXD005802-2

PXD005802 is an original dataset announced via ProteomeXchange.

Title	Signaling and crosstalk of the angiotensin AT2-receptor and the receptor MAS
Description	The AT2-receptor (AT2R) and the receptor MAS are GPCRs within the renin-angiotensin-system mediating protective actions. Their unconventional signaling mechanisms are still not well characterized, but those known display a high degree of similarity. The proposed project is part of a large-scale collaboration with the group of Robson Santos, a leader in Ang1-7/MAS research, aiming at a better characterization of AT2R-MAS signaling and crosstalk. Building up on our finding that the AT2R and MAS heterodimerise and on the mapping of the entire Ang-(1−7)/MAS signaling network by the Santos group, the proposed studies will look at AT2R-MAS signaling in two ways: mapping the AT2R signaling network by quantitative phosphoproteomics and compare it with the MAS network.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:41:12.739.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stefan J. Kempf
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-30 01:22:01	ID requested
1	2022-11-18 02:09:50	announced
⏵ 2	2024-10-22 05:41:13	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: proteomics, signalling,cardiovascular

Martin R. Larsen
contact affiliation	Department of Biochemistry and Molecular Biochemistry, University of Southern Denmark, Odense, Denmark
contact email	mrl@bmb.sdu.dk
lab head
Stefan J. Kempf
contact affiliation	University of Southern Denmark
contact email	kempf-stefan@t-online.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD005802

PRIDE project URI

• PRIDE
  1. PXD005802
     1. Label: PRIDE project
     2. Name: Signaling and crosstalk of the angiotensin AT2-receptor and the receptor MAS