PXD005726 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ECM characterization in stented porcine coronary arteries LC-MS/MS |
| Description | Bare-metal (BMS) and drug-eluting stents (DES) were implanted in pig coronary arteries with an overstretch during coronary angioplasty under optical coherence tomography guidance. Arteries subjected to plain old balloon angioplasty (POBA) alone served as controls. Stented/balloon dilated segments were harvested 1, 3, 7, 14 and 28 days post-intervention for proteomics analysis. At day 28 all stented arteries showed a neointima formation covering the stent struts. The evolved neointima was separated from the media and analysed in a separate proteomics analysis. In total, 31 samples were analysed for the media by LC-MS/MS (n=3 BMS/DES at each time-point 1, 3, 7 and 28 days; n=4 POBA early [day1-day3] and n=3 POBA late [day 14 - day28]). For the neointima a total of 14 samples were analysed (n=7 BMS, n=7 DES at 28 days) including the neointima of arteries of a second cohort with 4 samples each for BMS and DES day 28. The neointima samples were run in duplicates. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:18:29.103.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD005726 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Xiaoke Yin |
| SpeciesList | scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; |
| ModificationList | Oxidation; Carbamidomethyl; Deamidated:18O(1) |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2017-01-17 01:39:23 | ID requested | |
| 1 | 2017-11-24 02:07:25 | announced | |
| ⏵ 2 | 2024-10-22 04:18:30 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1161/circulationaha.116.023381; |
| Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski KP, Gasior P, Buszman PP, Buszman P, Jahangiri M, Shanahan CM, Hill J, Mayr M, Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation, 137(2):166-183(2018) [pubmed] |
| 10.6019/PXD005726; |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: coronary arteries, neointima, media,Pig, LC-MS/MS |
Contact List
| Manuel Mayr |
|---|
| contact affiliation | King's College London |
| contact email | manuel.mayr@kcl.ac.uk |
| lab head | |
| Xiaoke Yin |
|---|
| contact affiliation | Cardiovascular Division, King's College London |
| contact email | xiaoke.yin@kcl.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD005726 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005726
- Label: PRIDE project
- Name: ECM characterization in stented porcine coronary arteries LC-MS/MS
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