PXD005709-1
PXD005709 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Biomarkers discovery for Colorectal cancer liver metastasis |
Description | Identification of early diagnostic and prognostic biomarkers measurable in liquid biopsies remains a major challenge in oncology today. OMICs technologies cannot be applied on clinically precious human material as this is required in its integrity for routine pathology investigation. Hence all OMICs discovery today is done on residual and not clinically relevant material. In the study, we present a novel, non-destructive, procedure named EXPEL, which uses rapid, pressure-assisted, interstitial fluid extrusion, allowing for full clinical pathology and OMICs analysis (proteins, metabolites, miRNA and DNA) on the same specimen. To demonstrate this we engage in a simultaneous biomarker discovery and routine diagnostic analysis of human colorectal cancer and liver metastases. Biomarkers discovered with EXPEL methodology can be readily detected in human sera, allowing for unprecedented translation to the clinic. EXPEL method enables for the first time both clinicians and scientist to explore identical, fresh, clinical material regardless of origin and size. |
HostingRepository | PRIDE |
AnnounceDate | 2018-10-26 |
AnnouncementXML | Submission_2018-10-26_10:34:47.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Dominique Baiwir |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2017-01-16 01:51:38 | ID requested | |
⏵ 1 | 2018-10-26 10:34:48 | announced |
Publication List
Costanza B, Turtoi A, Bellahc, è, ne A, Hirano T, Peulen O, Blomme A, Hennequi, è, re V, Mutijima E, Boniver J, Meuwis MA, Josse C, Koopmansch B, Segers K, Yokobori T, Fahmy K, Thiry M, Coimbra C, Garbacki N, Colige A, Baiwir D, Bours V, Louis E, Detry O, Delvenne P, Nishiyama M, Castronovo V, Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9(12):10665-10680(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: human, colon cancer liver metastasis, proteomic |
Contact List
Vincent Castronovo | |
---|---|
contact affiliation | Metastases Research Laboratory, GIGA-CANCER, University of LIEGE, BELGIUM |
contact email | vcastronovo@ulg.ac.be |
lab head | |
Dominique Baiwir | |
contact affiliation | University of Liege |
contact email | D.Baiwir@ulg.ac.be |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005709 |
PRIDE project URI |
Repository Record List
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