PXD005706-2

PXD005706 is an original dataset announced via ProteomeXchange.

Title	Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells
Description	Experiments were performed assessing whether targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions could produce an effective therapeutic response in breast cancer, using both 2D and 3D culture models. CAIX inhibitors were shown to combine effectively with irradiation in clonogenic assays. Proteomic-mass-spectrometric analysis was carried out to analyze the possible mechanisms through which the CAIX inhibitor used was combining with irradiation.
HostingRepository	PRIDE
AnnounceDate	2017-05-02
AnnouncementXML	Submission_2017-05-12_01:43:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	James Meehan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-15 09:37:44	ID requested
1	2017-05-02 05:14:30	announced
⏵ 2	2017-05-12 01:43:05	announced	Updated publication reference for PubMed record(s): 28476026.

Meehan J, Ward C, Turnbull A, Bukowski-Wills J, Finch AJ, Jarman EJ, Xintaropoulou C, Martinez-Perez C, Gray M, Pearson M, Mullen P, Supuran CT, Carta F, Harrison DJ, Kunkler IH, Langdon SP, Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells. Oncotarget, 8(26):42857-42875(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Breast, Hypoxic, CAIX, irradiation

Simon P. Langdon
contact affiliation	Division of Pathology Laboratories, Institute of Genetics and Molecular Medicine, University of Edinburgh
contact email	Simon.Langdon@ed.ac.uk
lab head
James Meehan
contact affiliation	University of Edinburgh
contact email	J.Meehan@sms.ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD005706

PRIDE project URI

• PRIDE
  1. PXD005706
     1. Label: PRIDE project
     2. Name: Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells