PXD005620 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells |
Description | DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopitz, J. (2015) Protein Sci. 24, 1686-94; Lee, J., Ballikaya, S., Schonig, K., Ball, C. R., Glimm, H., Kopitz, J. & Gebert, J. (2013) PloS one. 8, e57074]. Whether this receptor expression in MSI tumor cells also impacts the exosomal proteomic cargo of these cells is still unknown. |
HostingRepository | PRIDE |
AnnounceDate | 2017-04-07 |
AnnouncementXML | Submission_2017-04-07_01:15:02.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD005620 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Fabia Fricke |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Deamidated; Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-12-22 02:14:11 | ID requested | |
⏵ 1 | 2017-04-07 01:15:03 | announced | |
Publication List
Fricke F, Lee J, Michalak M, Warnken U, Hausser I, Suarez-Carmona M, Halama N, Schn, ö, lzer M, Kopitz J, Gebert J, TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Commun Signal, 15(1):14(2017) [pubmed] |
Keyword List
submitter keyword: Exosomes, Proteomics, Transforming Growth Factor Beta Receptor Type 2, DNA Mismatch Repair Deficiency, Microsatellite Instability, Colorectal Cancer, LC-MSMS |
Contact List
Prof. Juergen Kopitz |
contact affiliation | PI, Dept. Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg |
contact email | juergen.kopitz@med.uni-heidelberg.de |
lab head | |
Fabia Fricke |
contact affiliation | PhD Student |
contact email | f.fricke@dkfz-heidelberg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/04/PXD005620 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005620
- Label: PRIDE project
- Name: TGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells