PXD005616 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Matrisome remodelling during Intervertebral Disc development and ageing |
Description | Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM remodelling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was used to define the NP matrisome. The enrichment of Collagen XII and XIV in foetus, Fibronectin and Prolargin in elder samples and Collagen XI in young ones was independently validated. This study provides the first matrisome database of healthy discs during development and ageing, which is key to determine the pathways and processes that maintain disc homeostasis. The factors identified may help to explain age-associated IVD degeneration or constitute putative effectors for disc regeneration. |
HostingRepository | PRIDE |
AnnounceDate | 2017-09-25 |
AnnouncementXML | Submission_2017-09-25_02:18:56.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD005616 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Hugo Osorio |
SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: 9913; |
ModificationList | iodoacetamide derivatized residue |
Instrument | 4700 Proteomics Analyzer |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-12-21 02:37:46 | ID requested | |
⏵ 1 | 2017-09-25 02:18:58 | announced | |
2 | 2024-10-22 04:35:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Caldeira J, Santa C, Os, ó, rio H, Molinos M, Manadas B, Gon, ç, alves R, Barbosa M, Matrisome Profiling During Intervertebral Disc Development And Ageing. Sci Rep, 7(1):11629(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Extracellular matrix, Intervertebral Disc, Ageing, Development, Foetus |
Contact List
Hugo Osorio |
contact affiliation | i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto Ipatimup - Institute of Molecular Pathology and Immunology of the University of Porto Rua Alfredo Allen, 208 4200-135 Porto Portugal |
contact email | hosorio@ipatimup.pt |
lab head | |
Hugo Osorio |
contact affiliation | IPATIMUP |
contact email | hosorio@ipatimup.pt |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/09/PXD005616 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005616
- Label: PRIDE project
- Name: Matrisome remodelling during Intervertebral Disc development and ageing