PXD005595-1

PXD005595 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Alzheimer's disease proteomics
Description	This project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pathogenic mechanism(s) that drive AD remain unclear, synapse loss is a pathological hallmark and correlates with cognitive decline. Abeta peptides accumulate due in large part to perturbed protein degradation pathways, and increasing evidence shows that Abeta peptides impair multiple cellular pathways. To advance our understanding of these complex processes we have completed a comprehensive proteomic characterization of the three different AD mouse models before and after the onset of pathology.
HostingRepository	MassIVE
AnnounceDate	2017-10-23
AnnouncementXML	Submission_2017-10-23_09:11:14.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Salvador Martínez de Bartolomé
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine
Instrument	LTQ Orbitrap Velos; LTQ Orbitrap Elite; Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-12-19 14:22:33	ID requested
⏵ 1	2017-10-23 09:11:15	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Alzheimer's disease, quantitative proteomics, proteostasis, amyloid, synapses

submitter keyword: Alzheimer's disease, quantitative proteomics, proteostasis, amyloid, synapses

Contact List

Jeffrey N. Savas, PhD
contact affiliation	Department of Neurology Northwestern University
contact email	jeffrey.savas@northwestern.edu
lab head
Salvador Martínez de Bartolomé
contact affiliation	The Scripps Research Institute
contact email	salvador@scripps.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080431

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080431