PXD005560-1

PXD005560 is an original dataset announced via ProteomeXchange.

Title	Identification of oxidative modifications of hemopexin and their physiological relevance
Description	This research provides novel insights into the underlying mechanism whereby the cyto- and neuro-protective heme binding protein hemopexin can be inactivated by reactive nitrogen species generated during the heme- and cytokine- driven inflammation that accompanies hemolysis. Nitration of amino acids is generally considered a selective and specific effect reflecting biological events. As we describe in a summary in the next paragraph, three tyrosine resides are preferentially targeted that reside in the heme binding site of apo-hemopexin. Hemopexin deficiency states develop in clinical sepsis and such modifications of hemopexin that we have identified and describe could also provide evidence-based guidance to physicians when heme toxicity is driving pathology to assess the timing and extent of hemopexin replenishment therapies and the patient responses to such treatment.
HostingRepository	MassIVE
AnnounceDate	2017-07-19
AnnouncementXML	Submission_2017-07-19_12:53:30.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Prof Ann Smith
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; scientific name: Oryctolagus cuniculus; common name: rabbit; NCBI TaxID: 9986;
ModificationList	Nitro; (35)Cl labeled 3'-chlorotyrosine; (35)Cl labeled 3',5'-dichlorotyrosine; t-butyl ester (OtBu) and t-butyl (tBu); Carbamidomethyl
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2016-12-13 15:13:19	ID requested
⏵ 1	2017-07-19 12:53:31	announced

no publication

submitter keyword: hemopexin, tyrosine nitration, mass spectrometry, proteomics, reactive oxygen species, covalent modification, reactive nitrogen species

Dr. Ann Smith
lab head
Prof Ann Smith
contact affiliation	University of Missouri-K.C.
contact email	smithan@umkc.edu
dataset submitter

MassIVE dataset URI

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080394