PXD005521 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic characterization of stem cell-derived extracellular matrices |
| Description | We characterized and compared the proteomic composition of ECM produced in vitro by bone marrow-derived MSC, adipose-derived MSC and neonatal fibroblasts isolated from different donors, employing a multidimensional proteomic approach coupled with label-based quantitative proteomics. Each cell-derived ECM displayed a specific and unique matrisome signature, yet they all shared a common set of proteins. We evaluated the biological response of cells cultured on the different matrices and compared them to cells on standard TCPS. The matrices lead to differential proliferation and gene expression profiles between the cell types and as compared to TCPS, indicating that the cell-derived ECM influence each cell type in a unique manner. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:34:16.465.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD005521 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Amanda Del Rosario |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | Deamidated; Oxidation; Carbamyl; Gln->pyro-Glu |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2016-12-07 05:30:14 | ID requested | |
| 1 | 2017-03-08 08:25:44 | announced | |
| ⏵ 2 | 2024-10-22 04:34:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| curator keyword: Biomedical |
| submitter keyword: LC-MS-MS, human,ECM |
Contact List
| Amanda Del Rosario |
|---|
| contact affiliation | Massachusetts Institute of Technology |
| contact email | aweaver@mit.edu |
| lab head | |
| Amanda Del Rosario |
|---|
| contact affiliation | Janssen Pharmaceuticals |
| contact email | adelros1@its.jnj.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/03/PXD005521 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005521
- Label: PRIDE project
- Name: Proteomic characterization of stem cell-derived extracellular matrices
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