PXD005445-5

PXD005445 is an original dataset announced via ProteomeXchange.

Title	CEGS Proteomics - A multiregional proteomic survey of the postnatal human brain
Description	Here we exploit label-free quantitative tandem mass-spectrometry proteomics to create the first in-depth quantitative proteomic survey of regions of the postnatal human brain. We adopted a dual approach to analysing these human brain samples similar to that of a recent high-quality study of the mouse brain proteome by Sharma et al, 2015. First was the discovery phase, designed to create a highly sensitive, heavily fractionated spectral library for each adult brain region. Then, to produce a quantitative run for each adult and postnatal development sample, single shot LC-MS/MS runs were used to accurately quantify proteins based on detected precursor peptide ion mass.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:42:44.037.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TuKiet Lam
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-25 01:58:12	ID requested
1	2017-09-26 07:08:26	announced
2	2017-12-06 09:29:25	announced	Updated publication reference for PubMed record(s): 29184206.
3	2018-01-08 04:41:46	announced	Updated project metadata.
4	2018-01-09 06:12:32	announced	Updated project metadata.
⏵ 5	2024-10-22 04:42:44	announced	2024-10-22: Updated project metadata.

10.1038/s41593-017-0011-2;

Carlyle BC, Kitchen RR, Kanyo JE, Voss EZ, Pletikos M, Sousa AMM, Lam TT, Gerstein MB, Sestan N, Nairn AC, A multiregional proteomic survey of the postnatal human brain. Nat Neurosci, 20(12):1787-1795(2017) [pubmed]

curator keyword: Biological

submitter keyword: human brain, regions, post natal development

TuKiet T. Lam
contact affiliation	Department of MBB Yale University MS & Proteomics Resource WM Keck Foundation Biotechnology Resource Lab
contact email	tukiet.lam@yale.edu
lab head
TuKiet Lam
contact affiliation	Yale University
contact email	tukiet.lam@yale.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD005445

PRIDE project URI

• PRIDE
  1. PXD005445
     1. Label: PRIDE project
     2. Name: CEGS Proteomics - A multiregional proteomic survey of the postnatal human brain