PXD005383-1

PXD005383 is an original dataset announced via ProteomeXchange.

Title	Mouse sciatic nerve LC-MSMS
Description	The peripheral nervous system (PNS) regenerates after injury. However regeneration is often compromised in case of large lesions, the speed of axon reconnection to their target being critical for successful functional recovery. After injury, mature Schwann cells (SCs) convert into repair cells that foster axonal regrowth, and redifferentiate to rebuild myelin. These processes require the regulation of several transcription factors, but the driving mechanisms remain partially understood. Here, we identify an early response to injury controlled by histone deacetylase (HDAC)2, which coordinates the action of other chromatin-remodeling enzymes to induce the upregulation of Oct6, a key transcription factor for Schwann cell development. Inactivating this mechanism using mouse genetics allows earlier conversion into repair cells and leads to faster axonal regrowth, but impairs remyelination. Consistently, short-term HDAC1/2 inhibitor treatment early after lesion accelerates functional recovery and enhances regeneration, thereby identifying a new therapeutic strategy to improve PNS regeneration after lesion.
HostingRepository	PRIDE
AnnounceDate	2018-10-18
AnnouncementXML	Submission_2018-10-18_01:24:24.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfred Heller
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-17 05:29:11	ID requested
⏵ 1	2018-10-18 01:24:26	announced

Br, ü, gger V, Duman M, Bochud M, M, ü, nger E, Heller M, Ruff S, Jacob C, Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nat Commun, 8():14272(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mouse sciatic nerve LC-MSMS

Claire Jacob
contact affiliation	Department of Biology University of Fribourg Chemin du Musée 10 Room 1.302 CH-1700 Fribourg Switzerland
contact email	claire.jacob@unifr.ch
lab head
Manfred Heller
contact affiliation	University of Bern
contact email	manfred.heller@dkf.unibe.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005383

PRIDE project URI

• PRIDE
  1. PXD005383
     1. Label: PRIDE project
     2. Name: Mouse sciatic nerve LC-MSMS