PXD005343-2

PXD005343 is an original dataset announced via ProteomeXchange.

Title	Proteome of Tcte1 deficient mouse sperm
Description	Sperm motility is one of the most important determinants of male fertility. Elucidating the different expression proteins of nomal and asthenospermia spermatozoa should advance our understanding of the underlying molecular mechanisms. Tcte1 null mouse sperm reduced motility and failed to display the forward progressive motile. With tandem mass tag (TMT) labeling and mass spectrometry analysis， 3697 proteins were quantified from Widetype and Tcte1 deficient mouse spermatozoa. Of these proteins, 447 were found to be different expression proteins (DEPs), including 398 proteins down regulated (DDEPs, 89%) and only 49 proteins up regulated.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:34:28.066.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tao Zhou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-14 05:25:06	ID requested
1	2018-02-09 09:02:03	announced
⏵ 2	2024-10-22 04:34:36	announced	2024-10-22: Updated project metadata.

10.1073/pnas.1621279114;

Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM, Liu M, TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Proc Natl Acad Sci U S A, 114(27):E5370-E5378(2017) [pubmed]

submitter keyword: mouse, TMT6, sperm, Tcte1

Jiahao Sha
contact affiliation	State Key Laboratory of Reproductive Medicine, Nanjing Medical University
contact email	shajh@njmu.edu.cn
lab head
Tao Zhou
contact affiliation	Central Laboratory, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University
contact email	zhoutao@njmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/02/PXD005343

PRIDE project URI

• PRIDE
  1. PXD005343
     1. Label: PRIDE project
     2. Name: Proteome of Tcte1 deficient mouse sperm