PXD005205-1

PXD005205 is an original dataset announced via ProteomeXchange.

Title	Proteins modulated during persistent lymphocytic choriomeningitis virus infection
Description	The experimental data indicate that during a persistent infection, lymphocytic choriomeningitis virus (LCMV) may both directly or indirectly modulate the regulatory cellular processes and alter the cellular functions that are not critical for the survival, but are needed for the homeostasis in the organism. Two-dimensional differential in-gel electrophoresis (2D-DIGE) and MALDI-TOF MS/MS analyses were used to determine the cellular proteome response of HeLa cell line to persistent LCMV infection. Quantitative analysis revealed 24 differentially abundant proteins, half of which were up-regulated and the rest down-regulated. Functional categorization showed that LCMV-responsive proteins were mainly involved in metabolism, stress and defense responses. Among identified proteins, significant changes were found for peroxiredoxins, family of antioxidant enzymes. Decreased amount of these antioxidant proteins was accompanied with the elevation of ROS content in infected cells.
HostingRepository	PRIDE
AnnounceDate	2019-11-15
AnnouncementXML	Submission_2019-11-15_00:04:42.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005205
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maksym Danchenko
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ultraflex

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-21 07:45:05	ID requested
⏵ 1	2019-11-15 00:04:43	announced
2	2024-10-22 04:33:30	announced	2024-10-22: Updated project metadata.

Benej M, Danchenko M, Oveckova I, Cervenak F, Tomaska L, Grossmannova K, Polcicova K, Golias T, Tomaskova J, Quantitative Proteomics Reveal Peroxiredoxin Perturbation Upon Persistent Lymphocytic Choriomeningitis Virus Infection in Human Cells. Front Microbiol, 10():2438(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: LCMV, arenavirus, host response, 2D-DIGE, peroxiredoxins

Jana Tomášková
contact affiliation	Department of Molecular Medicine, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences
contact email	virujato@savba.sk
lab head
Maksym Danchenko
contact affiliation	Institute of Virology, Biomedical Research Center SAS
contact email	maxymdan@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD005205

PRIDE project URI

• PRIDE
  1. PXD005205
     1. Label: PRIDE project
     2. Name: Proteins modulated during persistent lymphocytic choriomeningitis virus infection