PXD005178 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Oligopeptide Importers AliC and AliD of Nonencapsulated Streptococcus pneumoniae Facilitate Mucosal Infections and Mediate Persistence during Invasive Disease |
Description | Nonencapsulated Streptococcus pneumoniae (NESp) is an emerging human pathogen that colonizes the nasopharynx and is associated with noninvasive disease such as otitis media (OM), conjunctivitis, and nonbacteremic pneumonia. For decades, expression of a polysaccharide capsule appeared to be necessary for establishment of colonization and development of invasive pneumococcal disease (IPD). Accordingly, the currently licensed pneumococcal vaccines target the polysaccharide capsule. However, NESp expressing the novel oligopeptide importer proteins AliC and AliD have been isolated during IPD. Our study reveals that NESp expressing AliC and AliD have intensified virulence compared to isogenic mutants, and we provide insight about how this pneumococcal population has become associated with IPD. Our data demonstrates that AliC and AliD enhance murine nasopharyngeal colonization and are required for OM in a chinchilla model. Furthermore, AliC and AliD increase pneumococcal survival in chinchilla whole blood and decrease deposition of human C3b on the bacterial surface. As NESp become an increasing threat to public health, our study exposes specific virulence factors to possibly target for a broadened prevention of IPD through vaccination. |
HostingRepository | PRIDE |
AnnounceDate | 2018-01-22 |
AnnouncementXML | Submission_2018-01-22_04:21:03.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ken Pendarvis |
SpeciesList | scientific name: Streptococcus pneumoniae; NCBI TaxID: 1313; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-10-18 01:23:22 | ID requested | |
⏵ 1 | 2018-01-22 04:21:04 | announced | |
Publication List
Bradshaw JL, Pipkins HR, Keller LE, Pendarvis JK, McDaniel LS, Are Enhanced by Oligopeptide Binding Proteins AliC and AliD. mBio, 9(1):(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Streptocuccus pneumoniae pneumococcus MHZ41 LTQ Velos Linear Trap |
Contact List
Larry S. McDaniel |
contact affiliation | Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America |
contact email | lmcdaniel@umc.edu |
lab head | |
Ken Pendarvis |
contact affiliation | Veterinary Science and Microbiology |
contact email | jkpendarvis@email.arizona.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005178
- Label: PRIDE project
- Name: Oligopeptide Importers AliC and AliD of Nonencapsulated Streptococcus pneumoniae Facilitate Mucosal Infections and Mediate Persistence during Invasive Disease