PXD005144 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chronic pancreatitis vs pancreatic cancer LC-MS |
| Description | Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By radiology the evaluation of a pancreatic mass, i.e. the differential diagnosis between CP and PC is often difficult. Preoperative needle biopsies are difficult to obtain and are demanding to interpret. New blood based biomarkers are needed. The accuracy of the only established biomarker for PC, CA 19-9 is rather poor in differentiating between benign and malignant mass of the pancreas. In this study, we have performed mass spectrometry HDMSE analysis of serum samples from patients with chronic pancreatitis and pancreatic cancer. We have quantified 652 proteins and performed detailed statistical analysis such as principal component analysis, orthogonal partial least square discriminant analysis and receiver operating curve analysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:33:16.651.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sakari Joenväärä |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2016-10-13 02:27:01 | ID requested | |
| 1 | 2017-06-09 04:09:35 | announced | |
| ⏵ 2 | 2024-10-22 04:33:24 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Saraswat M, Joenv, ä, ä, r, ä S, Sepp, ä, nen H, Mustonen H, Haglund C, Renkonen R, Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis. Cancer Med, 6(7):1738-1751(2017) [pubmed] |
| 10.1002/cam4.1107; |
Keyword List
| curator keyword: Biomedical |
| submitter keyword: Multivariate data analysis, LC-MS,Chronic pancreatitis, pancreatic ductal adenocarcinoma, label-free qunatification, pancreatic cancer |
Contact List
| Risto Renkonen |
|---|
| contact affiliation | Transplantation Laboratory, Haartman Institute, University of Helsinki, Finland |
| contact email | risto.renkonen@helsinki.fi |
| lab head | |
| Sakari Joenväärä |
|---|
| contact affiliation | Helsinki University |
| contact email | sakari.joenvaara@helsinki.fi |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005144
- Label: PRIDE project
- Name: Chronic pancreatitis vs pancreatic cancer LC-MS
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