PXD004998-1

PXD004998 is an original dataset announced via ProteomeXchange.

Title	Detection of Five Solid Carcinomas Using Blood Circulating Proteins
Description	When diagnosed in a metastatic stage cancer is mostly incurable making its early detection via biomarkers of immense clinical interest. Proteins circulating in blood are a preferred source of biomarkers for a wide range of cancers due to the ease and non-invasiveness of collection. Our approach to cancer biomarker discovery is based on the observation that proteomic changes in tumor tissue are remotely detectable as changes in the protein composition of blood plasma. To determine whether these changes in the plasma of patients are specific for their specific cancer or represent a response to cancer in general we performed a cross-tumor plasma proteomic study. Using a proteomic serum/plasma workflow consisting of the combined use of N-glycosite enrichment and SWATH mass spectrometry (SWATH-MS), we investigated 155 blood samples derived from cohorts of patients with carcinomas at a localized or locally advanced clinical stage, or from a matched control group. A quantitative comparison of the resulting N-glycosite profiles indicated that some biomarkers are common to several cancers, while others are highly specific for one cancer type.
HostingRepository	PRIDE
AnnounceDate	2018-08-09
AnnouncementXML	Submission_2018-08-09_08:29:45.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tatjana Sajic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; deamidated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-20 00:16:04	ID requested
⏵ 1	2018-08-09 08:29:46	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Biomarker, Plasma , N-glycoprotein, SWATH-MS

Ruedi Aebersold
contact affiliation	Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, CH-8093, Switzerland ( lab head )
contact email	aebersold@imsb.biol.ethz.ch
lab head
Tatjana Sajic
contact affiliation	IMSB, ETH Zurich
contact email	sajic@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD004998

PRIDE project URI

• PRIDE
  1. PXD004998
     1. Label: PRIDE project
     2. Name: Detection of Five Solid Carcinomas Using Blood Circulating Proteins