PXD004985 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Salmon liver proteomics |
Description | Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19°C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in thermal adaptation. With the aim of identifying the mechanisms underlying liver plasticity in response to chronic elevated temperature in Atlantic salmon, label-free quantitative shotgun proteomics was used to explore quantitative protein changes after 43 days of exposure to elevated temperature. A total of 277 proteins were differentially (adjusted p-value <0.05) expressed between the control (15°C) and elevated (21°C) temperature treatments. As predicted identified by Ingenuity pathway analysis (IPA), transcription and translation mechanisms, protein degradation via the proteasome, and cytoskeletal components were down-regulated at elevated temperature. In contrast, an up-regulated response was predicted identified for NRF2-mediated oxidative stress, endoplasmic reticulum stress, and amino acid degradation. The proteome response was paralleled by reduced fish condition factor and hepato-somatic index at elevated temperature . The present study provides further evidence of the interplay among different cellular machineries in a scenario of heat-induced energy deficit and oxidative stress, and refines present understanding of how Atlantic salmon cope with chronic exposure to temperature near the upper limits of thermal tolerance. |
HostingRepository | PRIDE |
AnnounceDate | 2018-03-01 |
AnnouncementXML | Submission_2018-03-01_02:36:50.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Richard Wilson |
SpeciesList | scientific name: Atlantic salmon; NCBI TaxID: 8030; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-09-16 02:32:07 | ID requested | |
⏵ 1 | 2018-03-01 02:36:52 | announced | |
Publication List
Nuez-Ort, í, n WG, Carter CG, Nichols PD, Cooke IR, Wilson R, Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature. BMC Genomics, 19(1):133(2018) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Thermal stress, Aquaculture, Proteomics |
Contact List
Richard Wilson |
contact affiliation | Proteomics facility manager |
contact email | richard.wilson@utas.edu.au |
lab head | |
Richard Wilson |
contact affiliation | University of Tasmania |
contact email | richard.wilson@utas.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004985
- Label: PRIDE project
- Name: Salmon liver proteomics