PXD004756-2

PXD004756 is an original dataset announced via ProteomeXchange.

Title	TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Description	Whole proteome quantification identified upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:32:12.016.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-11 00:00:59	ID requested
1	2021-03-04 12:16:55	announced
⏵ 2	2024-10-22 04:32:20	announced	2024-10-22: Updated project metadata.

Schwenk BM, Hartmann H, Serdaroglu A, Schludi MH, Hornburg D, Meissner F, Orozco D, Colombo A, Tahirovic S, Michaelsen M, Schreiber F, Haupt S, Peitz M, Br, ü, stle O, K, ü, pper C, Klopstock T, Otto M, Ludolph AC, Arzberger T, Kuhn PH, Edbauer D, TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. EMBO J, 35(21):2350-2370(2016) [pubmed]

curator keyword: Biological

submitter keyword: FTLD, recycling endosomes,TDP-43, ALS, ErbB4

Felix Meissner
contact affiliation	Max Planck Institute of Biochemistry Experimental Systems Immunology Am Klopferspitz 18 82152 Martinsried/Munich Germany
contact email	meissner@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD004756

PRIDE project URI

• PRIDE
  1. PXD004756
     1. Label: PRIDE project
     2. Name: TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons