PXD004741-2

PXD004741 is an original dataset announced via ProteomeXchange.

Title	Mouse ciliopathy-associated CPLANE proteins
Description	Combining proteomics, in vivo imaging and genetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified and characterized a new genetic module, which we term CPLANE (ciliogenesis and planar polarity effector), and an extensive associated protein network. CPLANE proteins physically and functionally interact with the poorly understood ciliopathy-associated protein Jbts17 at basal bodies, where they act to recruit a specific subset of IFT-A proteins. In the absence of CPLANE, defective IFT-A particles enter the axoneme and IFT-B trafficking is severely perturbed. Accordingly, mutation of CPLANE genes elicits specific ciliopathy phenotypes in mouse models and is associated with ciliopathies in human patients.
HostingRepository	PRIDE
AnnounceDate	2017-01-17
AnnouncementXML	Submission_2017-01-17_07:31:15.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD004741
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Janos Demeter
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Phospho; Propionamide; Glu->pyro-Glu; Deamidated; Methyl; Oxidation; Acetyl; GlyGly; Gln->pyro-Glu
Instrument	LTQ Orbitrap Velos; LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-09 02:59:17	ID requested
1	2016-08-15 03:59:36	announced
⏵ 2	2017-01-17 07:31:16	announced	Updated project metadata.

curator keyword: Biological

submitter keyword: Mouse, ciliopathy, CPLANE, "Planar Cell Polarity”, “Human Genetics"

Peter K. Jackson
contact affiliation	Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine 269 Campus Drive CCSR 3205b Stanford, CA 94305-5175
contact email	pjackson@stanford.edu
lab head
Janos Demeter
contact affiliation	Stanford University
contact email	jdemeter@stanford.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004741
     1. Label: PRIDE project
     2. Name: Mouse ciliopathy-associated CPLANE proteins