PXD004643-1

PXD004643 is an original dataset announced via ProteomeXchange.

Title	PP1 interactome during heart failure development
Description	The PP1 interactome plays a central role in HF pathogenesis and is dysregulated at the level of the R-subunits in the failing heart, resulting in differential phosphorylation status of proteins across different subcellular compartments.With the combination if immunoaffinity purification and mass spectrometry we were able to map the PP1 interactome in a mouse model with dilated cardiomyopaty, which is the most common form of primary cardiomyopaty leading to HF.
HostingRepository	PRIDE
AnnounceDate	2018-04-11
AnnouncementXML	Submission_2018-04-11_00:49:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eleonora Corradini
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-25 01:27:49	ID requested
⏵ 1	2018-04-11 00:49:09	announced
2	2024-10-22 04:31:14	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: PP1, PPI, heart failure, immunoprecipitation, LC-MS/MS,

Albert J.R. Heck
contact affiliation	Biomolecular mass spectrometry and proteomics group, Utrecht University
contact email	a.j.r.heck@uu.nl
lab head
Eleonora Corradini
contact affiliation	Biomolecular and mass spectrometry group
contact email	e.corradini1@uu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD004643

PRIDE project URI

• PRIDE
  1. PXD004643
     1. Label: PRIDE project
     2. Name: PP1 interactome during heart failure development