PXD004636-2

PXD004636 is an original dataset announced via ProteomeXchange.

Title	Nanoparticle protein corona LC-MS/MS
Description	Engineered nanoparticles for biomedical applications require increased effectiveness in targeting specific cells while preserving non-target cells’ safety. Native nanoparticles entering a protein-rich liquid media quickly form a macromolecular structure called protein corona. This protein structure defines the physical interaction between nanoparticles and target cells. We describe SUSTU (surface proteomics for nanoparticle safety, targeting and uptake) a proteomics-based method to analyze the surface of a nanoparticle protein corona. This method provides qualitative and quantitative analysis from the protein corona surface. Those exposed proteins compose the first line of interaction between this macromolecular structure and the cell surface of a target cell. With SUSTU, the spatial and temporal dynamics of the protein corona surface can be studied. Data from SUSTU would ascertain the nanoparticle functionalized groups exposed at destiny; circumventing preliminary in vitro experiments. Therefore this method evaluates nanoparticle targeting and uptake capability and could be integrated into a rapid prototyping strategy which is a major challenge in nanomaterial science.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:49:23.836.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD004636
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jacob Kuruvilla
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	Phospho; Dehydrated; Oxidation; Acetyl; Carbamidomethyl; CAMthiopropanoyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-21 07:11:21	ID requested
1	2017-02-28 02:20:05	announced
⏵ 2	2023-11-14 08:49:24	announced	2023-11-14: Updated project metadata.

10.6019/PXD004636;

curator keyword: Technical, Biological

submitter keyword: protein corona (PC),Nanoparticle (NP), LC-MS/MS

Susana Christobal
contact affiliation	Department of clinical and experimental medicine, Linkoping University, Sweden.
contact email	susana.cristobal@liu.se
lab head
Jacob Kuruvilla
contact affiliation	Linkoping University
contact email	jacob.kuruvilla@liu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004636
     1. Label: PRIDE project
     2. Name: Nanoparticle protein corona LC-MS/MS