PXD004570-1
PXD004570 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome analyses of two ovarian clear cell carcinoma cell lines with or without ARID1A manipulation |
Description | ARID1A, which encodes a component of the SWI/SNF chromatin-remodeling complex, is commonly mutated in ovarian clear cell carcinoma and many other cancer types. We used label-free LC-MS/MS to identify ARID1A-dependent proteome changes in ovarian clear cell carcinoma cell lines. In our first analysis, we compared ARID1A-wildtype ovarian clear cell carcinoma cell line OVCA429 with or without ARID1A CRISPR knockout. In a complementary analysis, we compared ARID1A-mutated ovarian clear cell carcinoma cell line OVISE with or without ARID1A overexpression using a tet-inducible promoter. |
HostingRepository | MassIVE |
AnnounceDate | 2016-09-21 |
AnnouncementXML | Submission_2016-09-21_09:55:52.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Aaron Goldman |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Acetyl; Oxidation; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2016-07-13 05:35:15 | ID requested | |
⏵ 1 | 2016-09-21 09:55:52 | announced |
Publication List
Aaron R. Goldman, Benjamin G. Bitler, Zachary Schug, Jose R. Conejo-Garcia, Rugang Zhang, and David W. Speicher. The Primary Effect on the Proteome of ARID1A-Mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-Transcriptional Level. Mol Cell Proteomics mcp.M116.062539. First Published on September 21, 2016, doi:10.1074/mcp.M116.062539. |
Keyword List
submitter keyword: Ovarian clear cell carcinoma, ARID1A, BAF250a, SWI/SNF chromatin-remodeling complex, Ovarian cancer, Cancer, Human, LC-MS/MS, Epithelial ovarian cancer, Label-free quantitation, OVCA429, OVISE |
Contact List
David W. Speicher | |
---|---|
lab head | |
Aaron Goldman | |
contact affiliation | The Wistar Institute |
contact email | agoldman@wistar.org |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000079904 |