<<< Full experiment listing

PXD004570-1

PXD004570 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome analyses of two ovarian clear cell carcinoma cell lines with or without ARID1A manipulation
DescriptionARID1A, which encodes a component of the SWI/SNF chromatin-remodeling complex, is commonly mutated in ovarian clear cell carcinoma and many other cancer types. We used label-free LC-MS/MS to identify ARID1A-dependent proteome changes in ovarian clear cell carcinoma cell lines. In our first analysis, we compared ARID1A-wildtype ovarian clear cell carcinoma cell line OVCA429 with or without ARID1A CRISPR knockout. In a complementary analysis, we compared ARID1A-mutated ovarian clear cell carcinoma cell line OVISE with or without ARID1A overexpression using a tet-inducible promoter.
HostingRepositoryMassIVE
AnnounceDate2016-09-21
AnnouncementXMLSubmission_2016-09-21_09:55:52.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAaron Goldman
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListAcetyl; Oxidation; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-07-13 05:35:15ID requested
12016-09-21 09:55:52announced
Publication List
Aaron R. Goldman, Benjamin G. Bitler, Zachary Schug, Jose R. Conejo-Garcia, Rugang Zhang, and David W. Speicher. The Primary Effect on the Proteome of ARID1A-Mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-Transcriptional Level. Mol Cell Proteomics mcp.M116.062539. First Published on September 21, 2016, doi:10.1074/mcp.M116.062539.
Keyword List
submitter keyword: Ovarian clear cell carcinoma, ARID1A, BAF250a, SWI/SNF chromatin-remodeling complex, Ovarian cancer, Cancer, Human, LC-MS/MS, Epithelial ovarian cancer, Label-free quantitation, OVCA429, OVISE
Contact List
David W. Speicher
lab head
Aaron Goldman
contact affiliationThe Wistar Institute
contact emailagoldman@wistar.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000079904