PXD004284 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mouse Liver LC-MSMS |
Description | Advances in mass spectrometry have made the quantitative measurement of proteins across multiple samples a reality, allowing for the study of complex biological systems such as the metabolic syndrome. Although deregulation of lipid metabolism and increased hepatic storage of triacylglycerides are known to play a part in the onset of the metabolic syndrome, its molecular basis and dependency on dietary and genotypic factors are poorly characterized. Here, we used a rich experimental design with two different mouse strains, dietary and metabolic perturbations to generate a compendium of quantitative proteome data, using three mass spectrometry strategies. The data recapitulates known properties of the metabolic system and indicate differential molecular adaptation of the two mouse strains to perturbations, contributing to a better understanding of the metabolic syndrome. We show that high-quality, high-throughput proteomic datasets provide an unbiased broad overview of complex systems upon perturbation. |
HostingRepository | PRIDE |
AnnounceDate | 2016-12-22 |
AnnouncementXML | Submission_2016-12-22_02:40:43.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Eduard Sabidó |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ FT |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-06-06 07:44:22 | ID requested | |
⏵ 1 | 2016-12-22 02:40:44 | announced | |
2 | 2017-10-24 03:13:05 | announced | Updated project metadata. |
3 | 2024-10-22 04:30:34 | announced | 2024-10-22: Updated project metadata. |
Publication List
Terfve C, Sabid, ó E, Wu Y, Gon, ç, alves E, Choi M, Vaga S, Vitek O, Saez-Rodriguez J, Aebersold R, System-Wide Quantitative Proteomics of the Metabolic Syndrome in Mice: Genotypic and Dietary Effects. J Proteome Res, 16(2):831-841(2017) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: mouse, liver |
Contact List
Ruedi Aebersold |
contact affiliation | Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland Department of Science, Faculty of Science, University of Zürich, Zürich, Switzerland |
contact email | aebersold@imsb.biol.ethz.ch |
lab head | |
Eduard Sabidó |
contact affiliation | Centre de Regulació Genòmica |
contact email | eduard.sabido@crg.cat |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004284
- Label: PRIDE project
- Name: Mouse Liver LC-MSMS