PXD004278 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | MZH29 is a novel potent FLT3 tyrosine kinase inhibitor with activity of overcoming drug resistant mutations in AML |
Description | In this study, we screened a group of newly synthesized tyrosine kinase inhibitors, and discovered MZH29 was a potent FLT3 inhibitor. Remarkably, MZH29 is well tolerated and effective in the clinically known FLT3 mutants in the constructed BaF3 model cells. MZH29 could also lead to complete tumor regression in the mouse xenograft model and increases survival in the bone marrow engraftment model. Further proteomics study indicates that the inhibition effects of MZH29 and AC220 are in a similar manner. All the results present here support that MZH29 could be a promising candidate for both the FLT3 WT and drug resistance mutant AML. |
HostingRepository | PRIDE |
AnnounceDate | 2017-10-24 |
AnnouncementXML | Submission_2017-10-24_02:18:19.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wei Ge |
SpeciesList | scientific name: Apis mellifera (Honeybee); NCBI TaxID: 7460; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-06-06 02:54:44 | ID requested | |
1 | 2016-12-12 11:41:27 | announced | |
⏵ 2 | 2017-10-24 02:18:20 | announced | Updated project metadata. |
Publication List
Xu B, Zhao Y, Wang X, Gong P, Ge W, MZH29 is a novel potent inhibitor that overcomes drug resistance FLT3 mutations in acute myeloid leukemia. Leukemia, 31(4):913-921(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: tyrosine kinases inhibitor |
AML |
drug resistance |
mv4-11 |
Contact List
Wei Ge |
contact affiliation | National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences |
contact email | wei.ge@chem.ox.ac.uk |
lab head | |
Wei Ge |
contact affiliation | National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences |
contact email | wei.ge@chem.ox.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD004278 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004278
- Label: PRIDE project
- Name: MZH29 is a novel potent FLT3 tyrosine kinase inhibitor with activity of overcoming drug resistant mutations in AML