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PXD004089-2

PXD004089 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
DescriptionThis project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including DNA replication, DNA repair and cell cycle regulation. Furthermore, we mapped the changes in protein interactions of the MCM complex in response to DNA damage, identifying a new role for this complex in DNA repair. In summary, we demonstrate the complementarity of these approaches for the characterization of protein interactions within the MCM complex.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:29:07.012.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFrancois-Michel Boisvert
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-05-03 01:54:50ID requested
12016-08-09 02:15:12announced
22024-10-22 04:29:14announced2024-10-22: Updated project metadata.
Publication List
Dubois ML, Bastin C, L, é, vesque D, Boisvert FM, Comprehensive Characterization of Minichromosome Maintenance Complex (MCM) Protein Interactions Using Affinity and Proximity Purifications Coupled to Mass Spectrometry. J Proteome Res, 15(9):2924-34(2016) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: AP-MS, BioID, MCM complex
Contact List
Francois-Michel Boisvert
contact affiliationDepartment of Anatomy and Cell Biology, Faculty of Medecine and Health Sciences, Université de Sherbrooke
contact emailfm.boisvert@usherbrooke.ca
lab head
Francois-Michel Boisvert
contact affiliationUniversité de Sherbrooke
contact emailfm.boisvert@usherbrooke.ca
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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