PXD004073 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | iTRAQ quantification of hippocampal proteins in a mouse model of unpredictable maternal separation and maternal stress |
Description | Adverse experiences in early life are risk factors for the development of behavioral and physiological symptoms that can lead to psychiatric and cognitive disorders later in life. Some of these symptoms can be transmitted to the offspring, in some cases by non-genomic mechanisms involving germ cells. Using a mouse model of unpredictable maternal separation and maternal stress, we show that postnatal trauma alters coping behaviors in adverse conditions in exposed males when adult and in their adult male progeny. The behavioral changes are accompanied by increased glucocorticoid receptor (GR) expression and decreased DNA methylation of the GR promoter in the hippocampus. DNA methylation is also decreased in sperm cells of exposed males when adult. Transgenerational transmission of behavioral symptoms is prevented by paternal environmental enrichment, an effect associated with the reversal of alterations in GR gene expression and DNA methylation in the hippocampus of the male offspring. These findings highlight the influence of both, negative and positive environmental factors on behavior across generations, and the plasticity of the epigenome across life. |
HostingRepository | PRIDE |
AnnounceDate | 2018-10-26 |
AnnouncementXML | Submission_2018-10-26_06:21:10.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrea Mizzi Brunner |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-04-28 06:18:27 | ID requested | |
⏵ 1 | 2018-10-26 06:21:12 | announced | |
Publication List
Gapp K, Bohacek J, Grossmann J, Brunner AM, Manuella F, Nanni P, Mansuy IM, Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal Trauma. Neuropsychopharmacology, 41(11):2749-58(2016) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: paternal trauma, trangenerational inheritance, environmental enrichment, iTRAQ, mouse, hippocampus |
Contact List
Isabelle M Mansuy |
contact affiliation | ETH Zürich, D-HEST |
contact email | imansuy@ethz.ch |
lab head | |
Andrea Mizzi Brunner |
contact affiliation | Utrecht University |
contact email | a.m.brunner@uu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004073
- Label: PRIDE project
- Name: iTRAQ quantification of hippocampal proteins in a mouse model of unpredictable maternal separation and maternal stress