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PXD003784-1

PXD003784 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePRICKLE1 .
DescriptionIdentification of the protein associated to PRICKLE1. Components of the evolutionarily conserved developmental planar cell polarity (PCP) pathway were recently described to play a prominent role in cancer cell dissemination. However, the molecular mechanisms by which PCP molecules drive the spread of cancer cells remain largely unknown. PRICKLE1 encodes a PCP protein bound to the promigratory serine/threonine kinase MINK1. We identify RICTOR, a member of the mTORC2 complex, as a PRICKLE1-binding partner and show that the integrity of the PRICKLE1-MINK1-RICTOR complex is required for activation of AKT, regulation of focal adhesions and cancer cell migration. Disruption of the PRICKLE1-RICTOR interaction results in a strong impairment of breast cancer cell dissemination in xenograft assays. Finally, we show that up-regulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival.
HostingRepositoryPRIDE
AnnounceDate2024-10-07
AnnouncementXMLSubmission_2024-10-07_10:03:42.061.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAvais Daulat
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-03-14 04:43:59ID requested
12024-10-07 10:03:42announced
Publication List
10.1038/s41416-019-0448-z;
Daulat AM, Finetti P, Revinski D, Silveira Wagner M, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg JP, Bertucci F, ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer. Br J Cancer, 120(9):931-940(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: RICTOR, MINK1,PRICKLE1
Contact List
Avais M Daulat
contact affiliationCRCM, Cell Polarity, Cell signalling and Cancer “Equipe labellisée Ligue Contre le Cancer”, Inserm,U1068, Marseille, F-13009, France Institut Paoli-Calmettes, Marseille, F-13009, France Aix-Marseille Université, F-13284, Marseille, France CNRS, UMR7258
contact emailavais.daulat@inserm.fr
lab head
Avais Daulat
contact affiliationCRCM
contact emailavais.daulat@inserm.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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