PXD003747 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Myostatin Deficiency But Not Anti-Myostatin Blockade Induces Marked Proteomic Changes in Mouse Skeletal Muscle |
Description | Recent studies have reported the deleterious physiological and metabolic changes in Mstn-/- mice including impaired force generation and susceptibility to contraction-induced injury. Such observations have raised the concerns about the functional quality of the increased muscle resulting from therapeutic blockade of Mstn. Here we provide proteomic evidence to demonstrate that therapeutic Mstn inhibition has minimal effects on muscle proteome composition whereas the genetic ablation of Mstn induces marked changes. Furthermore, this study also represents the first proteomic analysis of the pharmacological blockage of the Mstn/activin receptor pathway being actively pursued as a potential therapy for multiple muscle wasting disorders. |
HostingRepository | PRIDE |
AnnounceDate | 2016-05-31 |
AnnouncementXML | Submission_2016-05-31_08:24:52.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Robert Salzler |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | 6x(13)C labeled residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-03-07 02:19:29 | ID requested | |
⏵ 1 | 2016-05-31 08:24:53 | announced | |
Publication List
Salzler RR, Shah D, Dor, é A, Bauerlein R, Miloscio L, Latres E, Papadopoulos NJ, Olson WC, MacDonald D, Duan X, Myostatin deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle. Proteomics, 16(14):2019-27(2016) [pubmed] |
Keyword List
submitter keyword: myostatin knockout, anti-myostatin blocking antibody, gastrocnemius, SILAC mouse, quantitative proteomics |
Contact List
Xunbao Duan |
contact affiliation | Regeneron Proteomics and Biomarkers |
contact email | Xunbao.duan@regeneron.com |
lab head | |
Robert Salzler |
contact affiliation | Regeneron |
contact email | robert.salzler@regeneron.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/05/PXD003747 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003747
- Label: PRIDE project
- Name: Myostatin Deficiency But Not Anti-Myostatin Blockade Induces Marked Proteomic Changes in Mouse Skeletal Muscle