PXD003710-2

PXD003710 is an original dataset announced via ProteomeXchange.

Title	Peli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis
Description	The ubiquitin ligase Peli1 has previously been suggested as a potential treatment target in multiple sclerosis since the knock-out induced less activated microglia and less inflammation in the CNS of experimental autoimmune encephalomyelitis in mice. In the present study the brain proteomes of Peli1 knock-out mice and wild-type mice were analyzed and compared before disease induction and after 10 and 20 days of experimental autoimmune encephalomyelitis using quantitative proteomics. The brain samples were analyzed using TMT labeling of small pools of samples and verified using label-free of individual mice.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:52.909.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eystein Oveland
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-29 02:33:24	ID requested
1	2016-09-26 17:48:33	announced
⏵ 2	2023-11-14 08:48:53	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: TMT, Label-free, EAE, CNS,Peli1, multiple sclerosis, quantitative proteomics

Frode Berven
contact affiliation	Proteomics Unit at University of Bergen (PROBE), Department of Biomedicine, University of Bergen, Norway.
contact email	frode.berven@uib.no
lab head
Eystein Oveland
contact affiliation	Institute of Marine Research
contact email	eysteino@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD003710

PRIDE project URI

• PRIDE
  1. PXD003710
     1. Label: PRIDE project
     2. Name: Peli1 knock-out and wild type mouse brain proteomes during the disease course of experimental autoimmune encephalomyelitis