PXD003646-3

PXD003646 is an original dataset announced via ProteomeXchange.

Title	Inflammatory signaling in human Tuberculosis granulomas is spatially organized
Description	Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissection and mass spectrometry , we generated detailed molecular maps of human granulomas. We found that the centers of granulomas possess a pro-inflammatory environment characterized by anti-microbial peptides, ROS and pro-inflammatory eicosanoids. Conversely, the tissue surrounding the caseum possesses a comparatively anti-inflammatory signature.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:10:32.027.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-16 07:44:41	ID requested
1	2016-02-26 01:03:56	announced
2	2016-04-11 00:45:05	announced	Updated publication reference for PubMed record(s): 27043495.
⏵ 3	2024-10-22 04:10:32	announced	2024-10-22: Updated project metadata.

10.1038/nm.4073;

Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, Dartois V, Rubin EJ, Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med, 22(5):531-8(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, LC-MSMS, Lung, Q Exactive, Granuloma, Mycobacterium

Matthias Mann
contact affiliation	Dept. Of Proteomics and Signal Transduction Max-Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried (near Munich) Germany
contact email	mmann@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD003646

PRIDE project URI

• PRIDE
  1. PXD003646
     1. Label: PRIDE project
     2. Name: Inflammatory signaling in human Tuberculosis granulomas is spatially organized