PXD003631 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Time-resolved adipocyte FGF21 phosphoproteome |
Description | To elucidate the signalling network responsible for mediating the effects of FGF21, we quantified the dynamic phosphoproteome of adipocytes following acute exposure to this hormone. A major FGF21-regulated signalling node was mTORC1/S6K. In contrast to insulin, we find that FGF21 activates mTORC1 via MAPK signalling rather than through the canonical PI3K/AKT pathway. This study provides a systems view of FGF21 signalling and reveals a new role for mTORC1 in maintaining nutrient homeostasis. |
HostingRepository | PRIDE |
AnnounceDate | 2016-08-15 |
AnnouncementXML | Submission_2016-08-15_08:45:50.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Sean Humphrey |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | LTQ Orbitrap Velos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-02-15 01:15:47 | ID requested | |
⏵ 1 | 2016-08-15 08:45:51 | announced | |
2 | 2024-10-22 04:10:04 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biological |
submitter keyword: FGF21, FGF-21, phosphoproteome, adipocyte, dynamic, SILAC |
Contact List
David E James |
contact affiliation | The Charles Perkins Centre School of Life and Environmental Sciences The University of Sydney Australia |
contact email | david.james@sydney.edu.au |
lab head | |
Sean Humphrey |
contact affiliation | Sydney University |
contact email | sean.humphrey@sydney.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003631 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003631
- Label: PRIDE project
- Name: Time-resolved adipocyte FGF21 phosphoproteome