PXD003631-1

PXD003631 is an original dataset announced via ProteomeXchange.

Title	Time-resolved adipocyte FGF21 phosphoproteome
Description	To elucidate the signalling network responsible for mediating the effects of FGF21, we quantified the dynamic phosphoproteome of adipocytes following acute exposure to this hormone. A major FGF21-regulated signalling node was mTORC1/S6K. In contrast to insulin, we find that FGF21 activates mTORC1 via MAPK signalling rather than through the canonical PI3K/AKT pathway. This study provides a systems view of FGF21 signalling and reveals a new role for mTORC1 in maintaining nutrient homeostasis.
HostingRepository	PRIDE
AnnounceDate	2016-08-15
AnnouncementXML	Submission_2016-08-15_08:45:50.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sean Humphrey
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-02-15 01:15:47	ID requested
⏵ 1	2016-08-15 08:45:51	announced
2	2024-10-22 04:10:04	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological

submitter keyword: FGF21, FGF-21, phosphoproteome, adipocyte, dynamic, SILAC

David E James
contact affiliation	The Charles Perkins Centre School of Life and Environmental Sciences The University of Sydney Australia
contact email	david.james@sydney.edu.au
lab head
Sean Humphrey
contact affiliation	Sydney University
contact email	sean.humphrey@sydney.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/08/PXD003631

PRIDE project URI

• PRIDE
  1. PXD003631
     1. Label: PRIDE project
     2. Name: Time-resolved adipocyte FGF21 phosphoproteome