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PXD003631 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTime-resolved adipocyte FGF21 phosphoproteome
DescriptionTo elucidate the signalling network responsible for mediating the effects of FGF21, we quantified the dynamic phosphoproteome of adipocytes following acute exposure to this hormone. A major FGF21-regulated signalling node was mTORC1/S6K. In contrast to insulin, we find that FGF21 activates mTORC1 via MAPK signalling rather than through the canonical PI3K/AKT pathway. This study provides a systems view of FGF21 signalling and reveals a new role for mTORC1 in maintaining nutrient homeostasis.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSean Humphrey
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListphosphorylated residue
InstrumentLTQ Orbitrap Velos; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-02-15 01:15:47ID requested
12016-08-15 08:45:51announced
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biological
submitter keyword: FGF21, FGF-21, phosphoproteome, adipocyte, dynamic, SILAC
Contact List
David E James
contact affiliationThe Charles Perkins Centre School of Life and Environmental Sciences The University of Sydney Australia
contact emaildavid.james@sydney.edu.au
lab head
Sean Humphrey
contact affiliationSydney University
contact emailsean.humphrey@sydney.edu.au
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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