PXD003580 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue] |
Description | Aiming to reduce smoking-related health risks, potential reduced risk products (pRRPs) are being developed. The Tobacco Heating System (THS) 2.2 is a recently developed pRRP, which utilizes the heat-not-burn principle. In this study, systems toxicology approaches were engaged to assess the respiratory effects of a mentholated version of THS2.2 (THS2.2M) in a 90-day rat inhalation study (OECD test guideline 413). This is the quantitative proteomics data set for rat lung tissue. As described in the sample processing protocol, two different iTRAQ sets were defined and analyzed separately. See i_Rat-THS2.2M-TG413_protItraq_LeftLung.xlsx for sample annotations and file mappings. |
HostingRepository | PRIDE |
AnnounceDate | 2016-12-13 |
AnnouncementXML | Submission_2016-12-12_16:26:33.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bjoern Titz |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | methylthiolated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-02-04 06:20:19 | ID requested | |
⏵ 1 | 2016-12-12 16:26:34 | announced | |
2 | 2017-10-24 02:38:04 | announced | Updated project metadata. |
Publication List
Kogel U, Titz B, Schlage WK, Nury C, Martin F, Oviedo A, Lebrun S, Elamin A, Guedj E, Trivedi K, Ivanov NV, Vanscheeuwijck P, Peitsch MC, Hoeng J, Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke. Regul Toxicol Pharmacol, 81 Suppl 2():S123-S138(2016) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: reduced risk tobacco product |
systems toxicology |
rat inhalation study |
iTRAQ |
Contact List
Julia Hoeng |
contact affiliation | Philip Morris R&D, Neuchatel, Switzerland |
contact email | julia.hoeng@pmi.com |
lab head | |
Bjoern Titz |
contact affiliation | Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland |
contact email | bjorn.titz@pmi.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003580
- Label: PRIDE project
- Name: Systems toxicological assessment of the mentholated Tobacco Heating System 2.2 product revealed reduced cellular and molecular exposure effects compared to cigarette smoke [quantitative proteomics of lung tissue]