PXD003282 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Clamping down on transcription: repression of archaeal RNAP by the novel viral regulator RIP |
Description | Little is known about how archaeal viruses perturbate the transcription machinery of their hosts. We provide the first example of a non-DNA binding archaeo-viral transcription factor that directly targets the host RNA polymerase and efficiently represses its activity. We have used cross-linking and mass spectrometry to identify how ORF145 binds in the DNA-binding channel of RNA polymerase. |
HostingRepository | PRIDE |
AnnounceDate | 2016-12-02 |
AnnouncementXML | Submission_2016-12-02_03:45:03.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Adam Belsom |
SpeciesList | scientific name: Sulfolobus solfataricus; NCBI TaxID: 2287; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-12-07 00:27:10 | ID requested | |
⏵ 1 | 2016-12-02 03:45:05 | announced | |
2 | 2017-10-24 02:00:27 | announced | Updated project metadata. |
Publication List
Sheppard C, Blombach F, Belsom A, Schulz S, Daviter T, Smollett K, Mahieu E, Erdmann S, Tinnefeld P, Garrett R, Grohmann D, Rappsilber J, Werner F, Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP. Nat Commun, 7():13595(2016) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: Transcription, RNA polymerase, archaea, evolution, virus, bacteriophages, repressor, cross-linking and mass spectrometry |
Contact List
Juri Rappsilber |
contact affiliation | 1. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom. 2. Department of Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany. |
contact email | juri.rappsilber@ed.ac.uk |
lab head | |
Adam Belsom |
contact affiliation | University of Edinburgh |
contact email | adam.belsom@ed.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD003282 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003282
- Label: PRIDE project
- Name: Clamping down on transcription: repression of archaeal RNAP by the novel viral regulator RIP