PXD003120 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Downregulation of LATS kinases alters p53 to promote cell migration |
Description | p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it partly shifts p53’s conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator. |
HostingRepository | PRIDE |
AnnounceDate | 2018-10-25 |
AnnouncementXML | Submission_2018-10-25_01:17:06.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yair Pozniak |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-10-29 03:21:20 | ID requested | |
⏵ 1 | 2018-10-25 01:17:07 | announced | |
Publication List
Furth N, Bossel Ben-Moshe N, Pozniak Y, Porat Z, Geiger T, Domany E, Aylon Y, Oren M, Down-regulation of LATS kinases alters p53 to promote cell migration. Genes Dev, 29(22):2325-30(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: TP53, Cox-2, cancer, cell-migration, NFKB2, homeostasis |
Contact List
Tamar Geiger |
contact affiliation | The Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel |
contact email | geiger@tauex.tau.ac.il |
lab head | |
Yair Pozniak |
contact affiliation | Tel Aviv University |
contact email | yair.poz@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD003120 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD003120
- Label: PRIDE project
- Name: Downregulation of LATS kinases alters p53 to promote cell migration