PXD003018-1

PXD003018 is an original dataset announced via ProteomeXchange.

Title	Myeloma cancer cells can corrupt mesenchymal stromal senescent cells and impair their anti-tumor activity
Description	Senescent cells secrete many molecules, which contribute to the prevention of cancer progression. We induced MSC senescence by oxidative stress, DNA damage, and replicative exhaustion. The first two are considered inducers of acute senescence while extensive proliferation triggers replicative senescence also named chronic senescence. We cultivated cancer cells in the presence of acute and chronic senescent MSC conditioned media and evaluated proliferation, DNA damage, apoptosis and senescence.
HostingRepository	PRIDE
AnnounceDate	2018-10-25
AnnouncementXML	Submission_2018-10-25_03:57:29.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	servet ozcan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2015-10-08 01:43:26	ID requested
⏵ 1	2018-10-25 03:57:31	announced

Ö, zcan S, Alessio N, Acar MB, Toprak G, G, ö, nen ZB, Peluso G, Galderisi U, Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity. Oncotarget, 6(37):39482-92(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Mesenchymal stem cells

senescence

secretome

apoptosis

cancer

Servet Özcan
contact affiliation	Erciyes University Genom and Stem Cell Center
contact email	servet3@gmail.com
lab head
servet ozcan
contact affiliation	Erciyes University, GENKOK
contact email	servet3@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD003018

PRIDE project URI

• PRIDE
  1. PXD003018
     1. Label: PRIDE project
     2. Name: Myeloma cancer cells can corrupt mesenchymal stromal senescent cells and impair their anti-tumor activity