PXD002913-1

PXD002913 is an original dataset announced via ProteomeXchange.

Title	Androgen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells
Description	Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic regulation of glycoprotein expression in the membrane fraction of prostate-tumor cells that could serve as mediators or markers of androgen-induced proliferative responses observed in prostate-tumor cells. A bioanalytical workflow involving lectin-affinity chromatography and label-free quantitative mass spectrometry was used to identify androgen-sensitive glycomembrane protein expression associated with androgen-mediated proliferation. This study would facilitate the identification of surface membrane proteins involved in androgen-mediated proliferation and provide potential therapeutic targets in the detection treatment of proliferation prostate-tumors.
HostingRepository	PRIDE
AnnounceDate	2024-10-08
AnnouncementXML	Submission_2024-10-08_11:10:20.722.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jordy Hsiao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	N-acetylaminoglucosylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	6520A Quadrupole Time-of-Flight LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2015-09-15 01:56:23	ID requested
⏵ 1	2024-10-08 11:10:21	announced

10.1038/S41598-021-01554-2;

curator keyword: Biomedical

submitter keyword: androgen,Human Prostate cancer cells, lectin affinity purification

Michael Eugene Wright
contact affiliation	Molecular Physiology & Biophysics Department , Wright Lab, University of Iowa, USA
contact email	michael-e-wright@uiowa.edu
lab head
Jordy Hsiao
contact affiliation	University of Iowa
contact email	jordy-hsiao@uiowa.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD002913
     1. Label: PRIDE project
     2. Name: Androgen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells