PXD002913 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Androgen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells |
Description | Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic regulation of glycoprotein expression in the membrane fraction of prostate-tumor cells that could serve as mediators or markers of androgen-induced proliferative responses observed in prostate-tumor cells. A bioanalytical workflow involving lectin-affinity chromatography and label-free quantitative mass spectrometry was used to identify androgen-sensitive glycomembrane protein expression associated with androgen-mediated proliferation. This study would facilitate the identification of surface membrane proteins involved in androgen-mediated proliferation and provide potential therapeutic targets in the detection treatment of proliferation prostate-tumors. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-08 |
AnnouncementXML | Submission_2024-10-08_11:10:20.722.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jordy Hsiao |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | N-acetylaminoglucosylated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | 6520A Quadrupole Time-of-Flight LC/MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-09-15 01:56:23 | ID requested | |
⏵ 1 | 2024-10-08 11:10:21 | announced | |
Publication List
Keyword List
curator keyword: Biomedical |
submitter keyword: androgen,Human Prostate cancer cells, lectin affinity purification |
Contact List
Michael Eugene Wright |
contact affiliation | Molecular Physiology & Biophysics Department , Wright Lab, University of Iowa, USA |
contact email | michael-e-wright@uiowa.edu |
lab head | |
Jordy Hsiao |
contact affiliation | University of Iowa |
contact email | jordy-hsiao@uiowa.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002913
- Label: PRIDE project
- Name: Androgen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells