PXD002650-2

PXD002650 is an original dataset announced via ProteomeXchange.

Title	Endothelial cell proteomic response to Rickettsia conorii infection
Description	Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the infected human, Rickettsia conorii infects endothelial cells, stimulating expression of cytokines and pro-coagulant factors. However, the integrated proteomic response of human endothelial cells to R. conorii infection is not known. In this study, we performed quantitative proteomic profiling of R conorii –infected primary HUVECs vs those stimulated with LPS alone.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_03:58:55.813.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingxin Zhao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-08-03 01:01:51	ID requested
1	2015-11-17 05:17:55	announced
⏵ 2	2024-10-22 03:58:56	announced	2024-10-22: Updated project metadata.

Zhao Y, Valbuena G, Walker DH, Gazi M, Hidalgo M, DeSousa R, Oteo JA, Goez Y, Brasier AR, Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/Cadherin Signaling. Mol Cell Proteomics, 15(1):289-304(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Endothelial cell, Rickettsia conorii, LC-MS/MS

Allan R. Brasier
contact affiliation	University of Texas Medical Branch
contact email	arbrasier@utmb.edu
lab head
Yingxin Zhao
contact affiliation	University of Texas Medical Branch
contact email	yizhao@utmb.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/11/PXD002650

PRIDE project URI

• PRIDE
  1. PXD002650
     1. Label: PRIDE project
     2. Name: Endothelial cell proteomic response to Rickettsia conorii infection