PXD002612-1

PXD002612 is an original dataset announced via ProteomeXchange.

Title	LC7 Proteomic Analysis of Matched Control and NSCLC Lung Adenocarcinoma Tissue.
Description	Non-small cell lung adenocarcinoma is the most frequently diagnosed lung cancer type and remains the leading cause of cancer mortality for men and women in the United States. Management of lung cancer is hindered by high false-positive rates due to the inability to resolve benign versus malignant tumors. Therefore, better molecular analysis comparing malignant and non-malignant tissues will provide additional evidence of the underlying biology contributing to tumorigenesis. In the current study, we utilized a proteomics approach to analyze 38 malignant and non-malignant paired tissue samples obtained from current or former smokers with early stage (Stage IA/IB) lung adenocarcinoma. Statistical mixed effects modeling and orthogonal partial least squares discriminant analysis were used to identify key cancer-associated perturbations in the malignant tissue proteome. Identified proteins were subsequently assessed against clinicopathological variables.
HostingRepository	PRIDE
AnnounceDate	2017-01-03
AnnouncementXML	Submission_2017-01-03_03:24:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brett Phinney
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-28 01:34:44	ID requested
⏵ 1	2017-01-03 03:24:27	announced
2	2017-10-24 03:35:15	announced	Updated project metadata.
3	2024-10-22 04:05:09	announced	2024-10-22: Updated project metadata.

Fahrmann JF, Grapov D, Phinney BS, Stroble C, DeFelice BC, Rom W, Gandara DR, Zhang Y, Fiehn O, Pass H, Miyamoto S, Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival. Clin Proteomics, 13():31(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, Lung Adenocarcinoma, Tissue, LC-MSMS

Suzanne Miyamoto
contact affiliation	UC Davis Internal medicine
contact email	smiyamoto@ucdavis.edu
lab head
Brett Phinney
contact affiliation	UC Davis Proteomics Core
contact email	bsphinney@ucdavis.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD002612

PRIDE project URI

• PRIDE
  1. PXD002612
     1. Label: PRIDE project
     2. Name: LC7 Proteomic Analysis of Matched Control and NSCLC Lung Adenocarcinoma Tissue.