PXD002488-1

PXD002488 is an original dataset announced via ProteomeXchange.

Title	Age effects in the extracellular matrix (ECM) proteome of the mouse left ventricle
Description	Matrix metalloproteinases (MMPs) collectively degrade all extracellular matrix (ECM) proteins. MMP-9 has the strongest link to development of cardiac dysfunction. Aging is associated with increased MMP-9 expression in the left ventricle (LV) and reduced cardiac function. We investigated the effect of MMP-9 deletion on the cardiac ECM in aged mice. Based on label-free mass spectrometry analyses, MMP-9 dependent age-related changes were found in the mouse cardiac ECM proteome, suggesting MMP-9 as a possible therapeutic target for the aging patient
HostingRepository	PRIDE
AnnounceDate	2018-07-05
AnnouncementXML	Submission_2018-07-05_06:09:18.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002488
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Susan Weintraub
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Ammonia-loss; Deamidated; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-06 06:33:05	ID requested
⏵ 1	2018-07-05 06:09:19	announced

Padmanabhan Iyer R, Chiao YA, Flynn ER, Hakala K, Cates CA, Weintraub ST, de Castro Br, á, s LE, Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart. Proteomics Clin Appl, 10(1):92-107(2016) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mouse, left ventricle, ECM proteome, aging HPLC-ESI-MS/MS

Susan T. Weintraub
contact affiliation	University of Texas Health Science Center at San Antonio
contact email	weintraub@uthscsa.edu
lab head
Susan Weintraub
contact affiliation	UT Health Science Center at San Antonio
contact email	weintraub@uthscsa.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD002488
     1. Label: PRIDE project
     2. Name: Age effects in the extracellular matrix (ECM) proteome of the mouse left ventricle