PXD002279-1

PXD002279 is an original dataset announced via ProteomeXchange.

Title	SLC12A3 isoforms in human urine exosomes
Description	The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. Human SLC12A3 gene encoding NCC gives rise to three isoforms. Only the isoform 3 has been extensively investigated. The goal of the present study was, therefore, to determine the abundance and localization of NCC1 and NCC2 in comparison to NCC3 in the human kidney as well as their functional properties in physiological and pathological conditions. To this end, the presence of NCC1, NCC2, and NCC3 in the human urinary exosomes was assessed by mass spectrometric analysis.
HostingRepository	PRIDE
AnnounceDate	2016-06-14
AnnouncementXML	Submission_2016-06-14_04:03:09.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sander Piersma
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-01 07:11:28	ID requested
⏵ 1	2016-06-14 04:03:11	announced
2	2024-10-22 04:24:28	announced	2024-10-22: Updated project metadata.

Tutakhel OA, Jele, ń S, Valdez-Flores M, Dimke H, Piersma SR, Jimenez CR, Deinum J, Lenders JW, Hoenderop JG, Bindels RJ, Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling. Am J Physiol Renal Physiol, 310(3):F204-16(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, urine, label-free, exosomes, isoforms

Connie Ramona Jimenez
contact affiliation	OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
contact email	c.jimenez@vumc.nl
lab head
Sander Piersma
contact affiliation	OncoProteomics Laboratory, dept of Medical Oncology, VUmc Medical Center, Amsterdam, The Netherlands
contact email	s.piersma@vumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/06/PXD002279

PRIDE project URI

• PRIDE
  1. PXD002279
     1. Label: PRIDE project
     2. Name: SLC12A3 isoforms in human urine exosomes