PXD002220-1

PXD002220 is an original dataset announced via ProteomeXchange.

Title	LPS-stimulated endothelial cells using SILAC
Description	Severe sepsis and septic shock, which occur with high incidence and are prevalent in the emergency department setting, are among the most common causes of death in hospitalized patients worldwide, and there has been a continuous increase in the incidence of sepsis of approximately 5–10% per year. Endothelial cells constitute an important metabolic organ in the physiological homeostasis of blood vessels and play a pivotal role in orchestrating the inflammatory response triggered by sepsis or endotoxemia. The secretome is defined as the subset of the proteome that contains all the proteins actively exported by a cell following a particular event.
HostingRepository	PRIDE
AnnounceDate	2015-10-05
AnnouncementXML	Submission_2015-10-05_04:48:12.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002220
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Oh Kwang Kwon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C: 4x(15)N labeled L-arginine; monohydroxylated residue; iodoacetamide derivatized residue; 6x(13)C: 2x(15)N labeled L-lysine
Instrument	LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2015-05-22 08:48:06	ID requested
⏵ 1	2015-10-05 04:48:13	announced

Kwon OK, Lee W, Kim SJ, Lee YM, Lee JY, Kim JY, Bae JS, Lee S, In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells. Electrophoresis, 36(23):2851-8(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Secretome, Biomarker, SILAC, Sepsis, Moesin

Sangkyu Lee
contact affiliation	College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea
contact email	sangkyu@knu.ac.kr
lab head
Oh Kwang Kwon
contact affiliation	Kyungpook National University
contact email	kok0100@nate.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD002220

PRIDE project URI

• PRIDE
  1. PXD002220
     1. Label: PRIDE project
     2. Name: LPS-stimulated endothelial cells using SILAC