PXD002010-2

PXD002010 is an original dataset announced via ProteomeXchange.

Title	Natural genetic variation on proteome level in Caenorhabditis elegans
Description	Natural genetic variation is the raw material of evolution and influences disease development and progression. To analyze the effect of the genetic background on protein expression in the nematode C. elegans (Caenorhabditis elegans), the two genetically highly divergent wild-type strains N2 (Bristol) and CB4856 (Hawaii) were compared quantitatively. In total, we quantified 3,238 unique proteins in three independent SILAC (stable isotope labeling by amino acids in cell culture) experiments. The differentially expressed proteins were enriched for genes that function in insulin-signaling and stress response pathways.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:21:11.518.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Polina Kamkina
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	6x(13)C; 6x(13)C; mono N-acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-04-02 00:44:41	ID requested
1	2016-03-11 07:39:54	announced
⏵ 2	2024-10-22 04:21:12	announced	2024-10-22: Updated project metadata.

Kamkina P, Snoek LB, Grossmann J, Volkers RJ, Sterken MG, Daube M, Roschitzki B, Fortes C, Schlapbach R, Roth A, von Mering C, Hengartner MO, Schrimpf SP, Kammenga JE, Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans. Mol Cell Proteomics, 15(5):1670-80(2016) [pubmed]

curator keyword: Biological

submitter keyword: C. elegans, CB4856, N2, SILAC, aging

Michael Otmar Hengartner
contact affiliation	Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
contact email	michael.hengartner@imls.uzh.ch
lab head
Polina Kamkina
contact affiliation	University of Zurich, Institute of Molecular Life Sciences
contact email	polina.kamkina@uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD002010

PRIDE project URI

• PRIDE
  1. PXD002010
     1. Label: PRIDE project
     2. Name: Natural genetic variation on proteome level in Caenorhabditis elegans